Desperation comes from doubt and confusion, fear, frustration, anger. Desperation, I would say, is living in hell, I would think this is how it feels. Therefore, yes, it keep us separate, separate from The Divine Self. This separation is because of our uncontrollable attachments and aversion. We suffer in the illusion of duality. Unable to recognize the very cause of our pain. We move from one desire to the next rapidly. In expectation that some external subjective reality will somehow provide the comfort we are desperately seeking. Only to remain in this confused state of insecurity, impermanence without any end in sight. Her Divine presence is permanent. She is the refuge of light in our heart eternally. We need only remember that, and we will never suffer desperation, or separation from our eternal Divine immortal Self.